Restless Legs Syndrome as an Atypical Case of PANDAS?
Tromba V, Spalice A, Lambiase C, Favoriti A and Tancredi G
Austin Journal of Clinical Medicine-2017
Our data confirm that patients with suspected restless leg
syndrome could present PANDAS.
Tromba V, Spalice A, Lambiase C, Favoriti A and Tancredi G
Austin Journal of Clinical Medicine-2017
Our data confirm that patients with suspected restless leg
syndrome could present PANDAS.
Pawela C, Brunsdon RK, Williams TA, Porter M, Dale RC, Mohammad SS
Dev Med Child Neurol-2016
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Although based on a small, cross‐sectional case series, our results highlight the potential importance of early identification and IVIg treatment of BGE. Given the cognitive and behavioural deficits described in this report, our clinical recommendation would be to try to treat patients rapidly with immune therapies, when clinical suspicion of BGE is high, to minimize the inflammatory component of the disease.
Kyle A. Williams, MD, PhD, Susan E. Swedo, MD, Cristan A. Farmer, PhD, Heidi Grantz, LCSW, Paul J. Grant, MD, Precilla D’Souza, CRNP, Rebecca Hommer, MD, Liliya Katsovich, MA, Robert A. King, MD, James F. Leckman, MD, Phd
Journal of the American Academy of Child & Adolescent Psychiatry–2016
IVIG was safe and well tolerated. Between-group differences were smaller than anticipated, and the double-blind comparison failed to demonstrate superiority of IVIG over placebo. The observed open-label improvements indicate that future trials would benefit from larger sample sizes designed in part to aid in the identification of biomarkers predictive of a positive response to immunotherapy. Future investigations focused on the natural history of PANDAS are also warranted.
Mechanisms by which microglial abnormalities contribute to disease are likely to be shared across distinct etiologies and traditional diagnoses. For instance, abnormal synaptic pruning was observed both in animals inoculated with GAS (which may capture key elements of the pathophysiology of PANDAS) and in mice that develop excessive grooming after inactivation of the progranulin gene. In both cases, increased synaptic pruning cooccurs with microglia activation.
Gaughan T, Buckley A, Hommer R, Grant P, Williams K, Leckman JF, Swedo SE
J Clin Sleep Med-2016
This study shows various forms of REM sleep motor disinhibition present in a population of children with PANS.
Chiara Spinello, Giovanni Laviola and Simone Macrì
Frontiers in Neuroscience – 2016
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In the present review we discuss the available evidence in preclinical models in support of the link between TS and pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections (PANDAS), and the existing gaps that future research shall bridge. Specifically, we report recent preclinical evidence indicating that the immune responses to repeated streptococcal immunizations relate to the occurrence of behavioral and neurological phenotypes reminiscent of TS.
David S. Younger, Phyllis A. Mast, and Denis A. Bouboulis
Journal of Neurology and Neurosurgery-2016
Children with PANDAS who had baseline low IgA, IgG or IgG subclass levels were more likely than others to achieve 100 % improvement after IVIg therapy at 12 months follow-up.
One Heart, One Mind gives families, as well as health professionals, a fresh look at how practical solutions to autism can be discovered in a book that offers exactly what parents are seeking:...
Çelik, Taş, Tahiroğlu, Avci , Yüksel, Çam
Noro Psikiyatr Ars-2017
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This study supports the hypothesis that an association between vitamin D metabolism and PANDAS-related OCD exists. We suggest that biochemical parameters predicting metabolic bone diseases are more common in PANDAS patients.
Y. Kulkarni, R. Warkari, “Pandas: A Rare Case Report”, International Journal of Science and Research (IJSR), Volume 5 Issue 2, February 2016, pp. 148-149, https://www.ijsr.net/get_abstract.php?paper_id=NOV161061
Abstract: PANDAS, also labelled as PANS, is a pediatric autoimmune neuropsychiatric disorder due to streptococcal infection. Although it affects 1 in 1000 children, cases reported in Indian context are relatively few because of lack of awareness about the syndrome amongst clinicians. We report here a case of a 13 years old male from a rural area presenting to us with an acute onset of repetitive behavior following a febrile illness 2 months prior. Investigations confirmed rheumatic valvular heart disease. A diagnosis of PANDAS was made and treatment was started. The patient responded to treatment and gained symptomatic relief. Timely intervention
and high index of suspicion towards a pediatric febrile illness can help to reduce the morbidity associated with this neuropsychiatric
disorder.
Graziella Orefici, PhD, Francesco Cardona, MD, Carol J. Cox, PhD, and Madeleine W. Cunningham, PhD.
From the Book: Streptococcus pyogenes Basic Biology to Clinical Manifestations – University of Oklahoma Health Sciences Center-2016
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The inclusion of a chapter on pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (or PANDAS) is essential to provide a history of the disease and provide current information about its association with Streptococcus pyogenes (group A streptococci), tics, obsessive compulsive disorder (OCD) and its relationship to Sydenham chorea (SC), which is the neurologic manifestation of acute rheumatic fever.