November Clinical Conversation: Understanding PANS and PANDAS

Presented by Michele Casoli Reardon, MD, MCPAP Medical Director and Pediatric Liaison, MGH for Children at North Shore Medical Center

A child is happy and easygoing one day, then literally overnight refuses to eat, sleep alone, or go to school. He or she may have tics, difficulty sleeping and headaches. The sudden, dramatic onset of symptoms, particularly following an infectious disease, should alert pediatricians to a possible diagnosis of pediatric acute-onset neuropsychiatric syndrome (PANS) or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS).